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Next meeting: Edinburgh, 26th April 2016


Tuesday 26th April 2016


The Roslin Institute



Information about travelling to the Roslin Institute can be found here.


Register to attend this meeting here.


Speaker Talk title Time
LUNCH LUNCH 12:30 - 13:30
Ian Jeffery (University College Cork, Ireland) Age-related Microbiome changes and their association with Dietary changes and Health 13:30 - 14:20
Annalaura Vacca (The University of Edinburgh) Meta-analysis of the induced immediately early response in 8 datasets 14:20 - 14:40
Dom Laetsch (The University of Edinburgh / James Hutton Institute, Dundee) Evolution of gene families within the phylum Nematoda 14:40 - 15:00

15:00 -

Siddharth Jayaraman (The Roslin Institute) Utilising long-read (PacBio) sequencing to analyse the dynamics of antigenic variation in Trypanosoma Brucei 15:30


Age-related Microbiome changes and their association with Dietary changes and Health

The increase in life expectancy has resulted in an ever increasing number of elderly individuals who are faced with unique age-related challenges when it comes to maintenance of their health and consequently their living independence.  Clinical issues such as inflamm-aging, sarcopenia and depression are particularly noteworthy in this regard.

The association between unhealthy diets and all-cause mortality is established but the importance of the role of the gut microbiota has only recently been widely recognized. To date, the largest gut microbiome study in an elderly population has been the ELDERMET study which showed that the intestinal microbiota composition is associated with long-term diet and the health status of the elderly individuals.

This presentation will define what constitutes age-related changes of the gut microbial system. It will discuss the role of composition and diversity of the microbiota in age-related health loss.  We will link these microbiota changes with age related dietary changes and other factors contributing to these changes. 

Ian’s presentation will discuss current scientific understanding and its potential health impacts.

  • How our gut microbiota changes as we age.
  • Observed links between the Elderly gut microbiota and the health status of the individual.
  • Lifestyle factors that may have a positive or negative impact on the bacterial ecosystem.
  • Options to modulate and/or protect the gut microbiota during Ageing.



James Prendergast, Ian Jeffery, Bert Overduin, Guillaume Devailly, Irene Cabeza, Colin Semple, Carlos Caurcel, Saikou Y Bah, Carlijn Bogaardt, Annalaura Vacca, Katherine Hayden, Yun-Yu Chen, Dom Laetsch, Siddarth Jayaraman, Erin Williams, Michal Stuglik, Sejal Modha, Christelle Robert, Pau Navarro, Rhea Kyriazopoulou, Stuart Aitken, Vince Mulholland, Siddharth Jayaraman, Quan Gu, Dan Robertson, Catherine Kidner, Kevin Mclean, Michaël Bekaert, Stewart Burgess, Katie Emelianova, Pietà Schofield, Deepali Vasoya, Lucía Campos Domínguez, Jamie Orr, Sam Lycett, Peter Cock, Nadejda Lupolova, Amanda Warr, Kathryn Elmer, Salvatore Galgano, Donald Dunbar, Lewis Stevens, Adrian Muwonge, Ramon Fallon, Ross Fraser, Frances Turner, Elisabet Sjokvist, Agnieszka Kloch, Javier Santoyo-Lopez, Murray Wham

NextGenBUG is co-ordinated and sponsored by Edinburgh Genomics, The University of Edinburgh's next generation genomics facility.